Bills vs. 49ers Week 13 Predictions, Odds and Stats

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When the Buffalo Bills match up with the San Francisco 49ers at 8:20 p.m. ET on Sunday, Dec. 1, our projection system predicts the Bills will take home the win. Our model also projects the spead, point total, and final score, which you can check out below.

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Bills vs. 49ers Game Info and TV Channel

  • When: Sunday, December 1, 2024 at 8:20 p.m. ET
  • Where: Highmark Stadium in Orchard Park, New York
  • TV: NBC
  • Live Stream: Watch this game on Fubo (Regional restrictions may apply)

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Bills vs. 49ers Odds and Betting Info

  • Spread favorite: Bills (-6.5)
  • Moneyline: Bills (-285), 49ers (+231)
  • Total: 44.5 points

Bills vs. 49ers Prediction

  • Pick ATS: Bills (-6.5)
  • Pick OU: Over (44.5)

Prediction:

Bills 31 - 49ers 17

    Prediction derived from a team strength comparison algorithm. Multiple factors such as strength of wins and scoring margin are used to make this projection.

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    Bills vs. 49ers Betting Insights

    • The Bills have put together a 7-4-0 ATS record so far this year.
    • The 49ers have won four games against the spread this season, failing to cover seven times.
    • Buffalo has covered the spread once this season (1-2 ATS) when playing as at least 6.5-point favorites.
    • San Francisco has not covered the spread this season (0-1 ATS) when playing as at least 6.5-point underdogs.
    • So far this season, seven out of the Bills' 11 games have gone over the point total.
    • In the 49ers' 11 contests this year, the combined scoring has gone over the point total six times.

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