49ers vs. Rams Week 15 Predictions, Odds and Stats

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Which team is going to win on Thursday, Dec. 12, when the San Francisco 49ers and Los Angeles Rams match up at 8:15 p.m. ET? Our projection model sides with the 49ers. Check out our other predictions below, where we break down the final score, spread, and over/under.

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49ers vs. Rams Game Info and TV Channel

  • When: Thursday, December 12, 2024 at 8:15 p.m. ET
  • Where: Levi's Stadium in Santa Clara, California
  • TV: Amazon Prime Video
  • Live Stream: Watch this game on Fubo (Regional restrictions may apply)
  • Live Stream: Watch this game on Prime Video (Regional restrictions may apply)

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49ers vs. Rams Odds and Betting Info

  • Spread favorite: 49ers (-2.5)
  • Moneyline: 49ers (-148), Rams (+124)
  • Total: 48.5 points

49ers vs. Rams Prediction

  • Pick ATS: Rams (+2.5)
  • Pick OU: Under (48.5)

Prediction:

49ers 25 - Rams 23

    Prediction derived from a team strength comparison algorithm. Multiple factors such as strength of wins and scoring margin are used to make this projection.

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    49ers vs. Rams Betting Insights

    • The 49ers are 5-8-0 ATS this season.
    • The Rams have put together a 6-7-0 record against the spread this year.
    • When playing as at least 2.5-point favorites this season, the 49ers have an ATS record of 5-6.
    • Los Angeles has been an underdog by 2.5 points or more seven times this season, and covered the spread in three of those contests.
    • So far this season, eight out of the 49ers' 13 games have hit the over.
    • Rams games have hit the over seven out of 13 times this year.

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