Duke vs. Cal Football Prediction & Odds - Oct. 4

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The Duke Blue Devils (3-2) and the California Golden Bears (4-1) square off on Saturday, October 4, 2025 at California Memorial Stadium in a clash of ACC opponents.

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Duke vs. Cal Matchup Info

  • Game date: Saturday, October 4, 2025
  • Game time: 10:30 p.m. ET
  • Location: Berkeley, California
  • Venue: California Memorial Stadium
  • TV channel: ESPN
  • Live Stream: Watch this game on Fubo (Regional restrictions may apply)

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Duke vs. Cal Odds and Prediction

  • Spread favorite: Blue Devils (-2.5)
  • Moneyline: Blue Devils (-144), Golden Bears (+121)
  • Total: 54.5 points
  • Pick ATS: Duke (-2.5)
  • Pick OU: Under (54.5)
  • Prediction: Duke 28, Cal 24

Prediction derived from a team strength comparison algorithm. Multiple factors such as strength of wins and scoring margin are used to make this projection.

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Duke vs. Cal Betting Records and Insights

  • Duke has covered twice in five matchups with a spread this season.
  • Cal has covered three times in five games with a spread this year.
  • The Blue Devils have covered the spread twice this season (2-1 ATS) when playing as at least 2.5-point favorites.
  • The Golden Bears have been an underdog by 2.5 points or more two times this season, and covered the spread both times.
  • A total of four out of five Duke games this season have hit the over.
  • Cal games have hit the over twice this year.

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