The USC Trojans (4-1) square off against a fellow Big Ten foe when they host the No. 15 Michigan Wolverines (4-1) on Saturday, October 11, 2025 at Los Angeles Memorial Coliseum.
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USC vs. Michigan Matchup Info
- Game date: Saturday, October 11, 2025
- Game time: 7:30 p.m. ET
- Location: Los Angeles, California
- Venue: Los Angeles Memorial Coliseum
- TV channel: NBC
- Live Stream: Watch this game on Fubo (Regional restrictions may apply)
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USC vs. Michigan Odds and Prediction
- Spread favorite: Trojans (-2.5)
- Moneyline: Trojans (-134), Wolverines (+113)
- Total: 56.5 points
- Pick ATS: USC (-2.5)
- Pick OU: Over (56.5)
- Prediction: USC 32, Michigan 29
Prediction derived from a team strength comparison algorithm. Multiple factors such as strength of wins and scoring margin are used to make this projection.
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USC vs. Michigan Betting Records and Insights
- USC has covered twice in five matchups with a spread this season.
- Michigan has a record of 2-3-0 against the spread this season.
- The Trojans have been favored by 2.5 points or more five times this season, and covered the spread in two of those matchups.
- The Wolverines have not covered the spread when an underdog by 2.5 points or more this season (in one opportunity).
- So far this season, four of USC's five games have hit the over.
- In 2025, three Michigan games have hit the over.