Notre Dame vs. USC Football Prediction & Odds - Oct. 18

The No. 13 Notre Dame Fighting Irish (4-2) host the No. 20 USC Trojans (5-1) at Notre Dame Stadium on Saturday, October 18, 2025.

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Notre Dame vs. USC Matchup Info

  • Game date: Saturday, October 18, 2025
  • Game time: 7:30 p.m. ET
  • Location: South Bend, Indiana
  • Venue: Notre Dame Stadium
  • TV channel: NBC
  • Live Stream: Watch this game on Fubo (Regional restrictions may apply)

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Notre Dame vs. USC Odds and Prediction

  • Spread favorite: Fighting Irish (-9.5)
  • Moneyline: Fighting Irish (-347), Trojans (+276)
  • Total: 61.5 points
  • Pick ATS: Notre Dame (-9.5)
  • Pick OU: Over (61.5)
  • Prediction: Notre Dame 40, USC 24

Prediction derived from a team strength comparison algorithm. Multiple factors such as strength of wins and scoring margin are used to make this projection.

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Notre Dame vs. USC Betting Records and Insights

  • Notre Dame has put together a 3-3-0 record against the spread this season.
  • USC has covered three times in six matchups with a spread this season.
  • The Fighting Irish have been favored by 9.5 points or more three times this season, and covered the spread in two of those contests.
  • So far this season, four of Notre Dame's six games have hit the over.
  • So far this year, four of USC's six games with a set number have hit the over.

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