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Which team is going to win on Sunday, Oct. 26, when the Houston Texans and San Francisco 49ers square off at 1 p.m. ET? Our projection model believes in the Texans. See our other projections below, where we break down the final score, spread, and over/under.
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Texans vs. 49ers Game Info and TV Channel
- When: Sunday, October 26, 2025 at 1 p.m. ET
- Where: NRG Stadium in Houston, Texas
- TV: FOX
- Live Stream: Watch this game on Fubo (Regional restrictions may apply)
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Listen to the game on SportsRadio 610
Texans vs. 49ers Odds and Betting Info
- Spread favorite: Texans (-1.5)
- Moneyline: Texans (-131), 49ers (+110)
- Total: 42 points
Texans vs. 49ers Prediction
- Pick ATS: Texans (-1.5)
- Pick OU: Under (42)
Prediction:
Texans 21 - 49ers 18
Prediction derived from a team strength comparison algorithm. Multiple factors such as strength of wins and scoring margin are used to make this projection.
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Texans vs. 49ers Betting Insights
- The Texans have won two games against the spread this season.
- The 49ers have compiled a 4-3-0 ATS record so far this season.
- Houston has covered the spread twice when favored by 1.5 points or more this season (in three opportunities).
- San Francisco has covered the spread once when an underdog by 1.5 points or more this year (in two opportunities).
- This season, games featuring the Texans have gone over the point total twice.
- The 49ers and their opponent have combined to go over the point total four out of seven times this season.
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