San Francisco 49ers running back Christian McCaffrey will face a middle-of-the-pack run defense in Week 11 (Sunday at 4:05 p.m. ET), versus the Arizona Cardinals. The Cardinals are ranked 18th in terms of rushing yards conceded, at 114.1 per game.
McCaffrey, who leads the team with 626 rushing yards on 180 attempts (62.6 ypg), also has four rushing TDs. McCaffrey is also the 49ers' most prolific receiver, as he's caught 69 passes for 692 yards (69.2 ypg) and four receiving touchdowns.
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McCaffrey vs. the Cardinals
- McCaffrey vs the Cardinals (since 2021): 3 GP / 100 RUSH YPG / 1 RUSH TD
- One opposing rusher has recorded 100 or more rushing yards in a matchup against the Cardinals during the 2025 season.
- Arizona has allowed eight opposing rushers to record one or more TDs on the groun against them this year.
- The Cardinals have allowed two or more rushing TDs to only one opposing rusher this season.
- The run defense of the Cardinals is conceding 114.1 yards per outing on the ground this season, which ranks 18th in the league.
- Opponents of the Cardinals have totaled nine touchdowns on the ground (1.0 per game). The Cardinals' defense is 16th in the NFL in that category.
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McCaffrey Rushing Insights
- McCaffrey hit the over on his rushing yards total set by sportsbooks in three of his 10 opportunities this season (30.0%).
- The 49ers have passed 57.3% of the time and run 42.7% this season. They rank 15th in the NFL in scoring.
- He has handled 66.7% of his team's 270 rushing attempts this season (180).
- McCaffrey has a rushing touchdown in three of 10 games this season, including multiple rushing TDs once.
- He has 34.8% of his team's 23 offensive touchdowns this season (eight).
- He has 35 red zone carries for 74.5% of the team share (his team runs on 47.5% of its plays in the red zone).
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McCaffrey's Recent Performance
| Opponent | Date | Week | Rushing Stats | Receiving Stats |
|---|---|---|---|---|
| vs. Rams | 11/9/2025 | Week 10 | 12 ATT / 30 YDS / 0 TDs | 10 TAR / 8 REC / 66 YDS / 0 TDs |
| vs. Giants | 11/2/2025 | Week 9 | 28 ATT / 106 YDS / 1 TD | 6 TAR / 5 REC / 67 YDS / 1 TD |
| vs. Texans | 10/26/2025 | Week 8 | 8 ATT / 25 YDS / 0 TDs | 6 TAR / 3 REC / 43 YDS / 0 TDs |
| vs. Falcons | 10/19/2025 | Week 7 | 24 ATT / 129 YDS / 2 TDs | 8 TAR / 7 REC / 72 YDS / 0 TDs |
| vs. Buccaneers | 10/12/2025 | Week 6 | 17 ATT / 54 YDS / 1 TD | 8 TAR / 7 REC / 57 YDS / 0 TDs |