The San Francisco 49ers should come out on top in their matchup versus the Tennessee Titans at 4:25 p.m. ET on Sunday, Dec. 14, according to our computer projection model. If you're looking for additional predictions on the final score, spread, and point total, we list those numbers below.
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49ers vs. Titans Game Info and TV Channel
- When: Sunday, December 14, 2025 at 4:25 p.m. ET
- Where: Levi's Stadium in Santa Clara, California
- TV: FOX
- Live Stream: Watch this game on Fubo (Regional restrictions may apply)
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Listen to the game on 107.7 The Bone
49ers vs. Titans Odds and Betting Info
- Spread favorite: 49ers (-12.5)
- Moneyline: 49ers (-901), Titans (+603)
- Total: 44.5 points
49ers vs. Titans Prediction
- Pick ATS: 49ers (-12.5)
- Pick OU: Under (44.5)
Prediction:
49ers 32 - Titans 12
Prediction derived from a team strength comparison algorithm. Multiple factors such as strength of wins and scoring margin are used to make this projection.
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49ers vs. Titans Betting Insights
- The 49ers have put together an 8-5-0 ATS record so far this year.
- The Titans have compiled a 6-7-0 ATS record so far this year.
- San Francisco has been favored by 12.5 points or more once this season, and covered the spread.
- Tennessee has been an underdog by 12.5 points or more six times this season, and covered the spread in four of those contests.
- So far this season, seven out of the 49ers' 13 games have hit the over.
- The Titans and their opponent have combined to hit the over eight out of 13 times this season.
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