Christian McCaffrey Week 16 Preview vs. the Colts

Christian McCaffrey will be up against the fourth-best rushing defense in the NFL when his San Francisco 49ers meet the Indianapolis Colts in Week 16, on Monday at 8:15 p.m. ET.

On the ground, McCaffrey has a team-leading 922 rushing yards on 259 carries (65.9 ypg), including nine rushing scores. Also, McCaffrey is the leading receiver for the 49ers, tacking on 86 receptions for 820 yards (58.6 ypg) and five receiving scores.

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McCaffrey vs. the Colts

• McCaffrey vs the Colts (since 2021): 1 GP / 54 RUSH YPG / 0 RUSH TD
• The Colts have allowed 100 or more yards to only one opposing rusher during the 2025 season.
• Indianapolis has allowed 10 opposing rushers to record one or more TDs on the groun against them this year.
• The Colts have allowed two or more rushing TDs to three opposing rushers this season.
• The Colts allow 95.1 yards per game on the ground, the NFL's fourth-ranked run defense this season.
• The Colts' defense ranks 13th in the NFL with 13 rushing TDs allowed so far this season.

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McCaffrey Rushing Insights

• McCaffrey has gone over his rushing yards total in 42.9% of his opportunities (six of 14 games).
• The 49ers have passed 54.3% of the time and run 45.7% this season. They rank 19th in the NFL in scoring.
• He has handled 64.1% of his team's 404 rushing attempts this season (259).
• McCaffrey has a rushing touchdown in seven games this year, including multiple rushing TDs twice.
• He has 37.8% of his team's 37 offensive touchdowns this season (14).
• He has 60 carries in the red zone (76.9% of his team's 78 red zone rushes).

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McCaffrey's Recent Performance